This article discusses pilot data for a major research project into the discursive construction of identity in three-generation families living in border communities where each generation has experienced fundamental changes in their socio-political environment. The oral data on which the analysis is based were triggered by photographs from the communities in question, and are being analysed with discourse-analytical procedures. The article demonstrates how an innovative method of using symbolically-charged photography as triggers for oral narratives can solve a major dilemma for (...) discourse analysts interested in oral data. It also demonstrates the processes of identity construction under highly conflictual circumstances. Using examples mainly taken from the narratives of three individuals from three different generations, living in a town on the border between the former GDR and West Germany, the article discusses the discursive means of coming to terms with different kinds of difficulties encountered by each generation in constructing for themselves an identity in the new Germany. (shrink)

Antibiotic development and usage, and antibiotic resistance in particular, are today considered global concerns, simultaneously mandating local and global perspectives and actions. Yet such global considerations have not always been part of antibiotic policy formation, and those who attempt to formulate a globally coordinated response to antibiotic resistance will need to confront a history of heterogeneous, often uncoordinated, and at times conflicting reform efforts, whose legacies remain apparent today. Historical analysis permits us to highlight such entrenched trends and processes, helping (...) to frame contemporary efforts to improve access, conservation and innovation. (shrink)

The debate on the role and identity of Christian social ethics in liberal democracy touches upon the question about the relationship between universality and specificity. Rather than argue for the difference between these approaches, it can be argued that they are to be understood in a differentiated unity with each other. This idea can be substantiated by a figurative appropriation of a Chalcedonian Christology, particularly the communicatio idiomatum . The communicative dimension of this concept has been found to be useful (...) for a reinterpretation of the idea of responsibility. By engaging contemporary positions of communicative ethics, H. Richard Niebuhr's understanding of responsibility as responsiveness, and Dietrich Bonhoeffer's Christological concept of responsibility in a constructive dialogue with each other, the article has attempted to outline main tenets of a responsive concept of responsibility based on a broadly conceived Chalcedonian Christology. This responsive understanding of responsibility serves as the foundation of a third position beyond the futile antagonism of liberalism and communitarianism. Hereby it maintains the reasonableness of a liberal democratic assertion of a common political discourse, and yet it also contends the necessity of authentic particular worldviews and outlooks. In its argument for such a third-way thinking it hopes to contribute with an understanding where these positions are seen in a constructive relationship – rather than in contrast – with each other. (shrink)

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

"Volkhard Knigge (Hg.): Jenseits der Erinnerung. Verbrechensgeschichte begreifen. Impulse für eine kritische Auseinandersetzung mit dem Nationalsozialismsus nach dem Ende der Zeitgenossenschaft, (unter Mitarbeit von Ulrike Löffler), Göttingen: Wallstein Verlag 2022, 428 S." published on 21 Jul 2023 by Brill.

The aim of this paper is to explore some of the possibilities, advantages and difficulties of corpus-based analyses of semantic and pragmatic aspects of language in one particular field, namely the linguistic expression of emotion concepts. For this purpose, a methodological procedure is proposed and an exemplary analysis of the emotion concept “fear” in English is performed. The procedure combines Kövecses' lexical approach and Stefanowitsch's metaphorical pattern analysis with additional concepts from corpus linguistics such as semantic preference and semantic prosody. (...) The results of the study show that such a corpus-based analysis of emotion words offers several advantages. Firstly, by exploring the surroundings of the search word in a vast amount of text, we are not only able to find evidence of conceptual metaphor and metonymy that structure the emotion concept and of related emotion concepts, but also we can enrich the description of the emotion concept with information from a series of dimensions and add a pragmatic viewpoint by revealing an explicit or implicit evaluation of the emotion. The second advantage offered by a corpus-based approach lies in the possibility of quantifying results, i.e., comparing the frequency, productivity and creative use of individual metaphors and metonymies, which is especially interesting in view of contrastive studies. (shrink)

Governing Europe is the first book to systematically link Michel Foucault's hypotheses on power and 'governmentality' with the study of European integration. Through a series of empirical encounters that spans the fifty-year history of European integration, it explores both the diverse political dreams that have framed means and ends of integration and the political technologies that have made 'Europe' a calculable, administrable domain. The book illustrates how a genealogy of European integration differs from conventional approaches. By suspending the assumption that (...) we already know what/where Europe is, it opens a space for analysis where we can ask: how did Europe come to be governed as this and not that? The themes covered by this book include: * the different constructions of Europe within discourses of modernization, democratization, insecurity and 'governance' * the imprint of modernism, liberalism, ordoliberalism, neoliberalism and crime on the identity of the European Community/European Union * the historical relationship between European government and specific technologies of power, technologies as diverse as planning, price control, transparency and benchmarking. (shrink)

This paper investigates the dynamic and performative construction of publics in public engagement exercises. In this investigation, we, on the one hand, analyse how public engagement settings as political machineries frame particular kinds of roles and identities for the participating publics in relation to ‘the public at large’. On the other hand, we study how the participating citizens appropriate, resist and transform these roles and identities, and how they construct themselves and the participating group in relation to wider publics. The (...) empirical basis of our argument is a discussion of four different kinds of participation events in Austria. Building on these observations we develop conclusions about the public up-take of public participation in technoscience and the role of public engagement in current techno-political cultures. (shrink)

Zwischen 1920 und 1925 kam es nach Vorarbeiten von Jones, Abraham, Stärcke, van Ophuijsen und Alexander sowie in Abrahams Hauptwerk, dem Versuch einer Entwicklungsgeschichte der Libido, zu einer Veränderung der psychoanalytischen Theorie, die sich vor allem auf die Stellung der Aggression bezog. Die stärkere Gewichtung der präödipalen Aggression wurde in London in erster Linie von Abrahams Analysanden James und Edward Glover durchgeführt. Ihre Arbeiten bereiteten den Boden für die Rezeption von Melanie Klein, einer weiteren Abraham-Analysandin, die ihrerseits von Alix Strachey, (...) auch sie eine Analysandin Abrahams, sowie von Ernest Jones unterstützt wurde. Klein entwickelte in der Analyse mit Kindern eine Technik, die sich bevorzugt auf die Wahrnehmung und Deutung der Aggression in der Stunde bezog. All dies, ohne dass Freud die neue Linie begrüßt hätte, was aber seit dem Erstarken der lokalen Gruppen in Berlin und London nicht mehr so stark ins Gewicht fiel. Gleichwohl blieb die Frage nach der Stellung der Aggression in der Schwebe, während sich Freud bis zuletzt für das Primat des Sexuellen aussprach und sich von den Positionen der hier erwähnten Schüler zwischen 1920 und 1925 mehrere Male ausdrücklich distanzierte. (shrink)

In this essay I examine the debate between Jürgen Habermas and Charles Taylor on the post-secular state. I argue that, although their views on the relation of religion and politics converge in certain respects, a profound difference remains between their overall approaches. Their disagreement on the epistemic status of religious as opposed to secular moral reasons, and on the role religious arguments can play in the public sphere testify to a deeper schism. Thus what might at first seem like a (...) quarrel about details proves to be a fundamental philosophical divide on the issue of modernity. I conclude that Taylor’s model of post-secularism is more promising as an approach to the challenge posed by growing religious and cultural diversity, for, if understood as a version of “reiterative universalism,” it avoids both moral relativism and Eurocentrism. (shrink)

Freuds Entwurf von »Trauer und Melancholie« vom Februar 1915, der 1996 publiziert wurde, steht im Zentrum der Untersuchung. Nach einer Zusammenfassung der Thesen des Entwurfs werden Ferenczis und Abrahams Reaktionen auf den Text sowie Freuds Kommentar zu ihren Stellungnahmen dargestellt. Freuds partielle Übernahme von Ferenczis Introjektion und seine Zurückhaltung gegenüber Abrahams »Munderotik und Sadismus« werden erörtert sowie die Frage, ob und inwiefern die Einwürfe der Schüler in die Endfassung von »Trauer und Melancholie« einflossen, insbesondere Abrahams theoretischer Ansatz. Abschließend wird der (...) Begriff der narzisstischen Identifizierung, der den Kern von Freuds Verständnis der Depression bildet, mit seinen aus der gleichen Zeit stammenden Ausführungen über die »Vorstufen der Liebe« zu einem Bild der narzisstischen Beziehung zwischen Subjekt und Objekt zusammengefügt, unter Betonung der klinischen Relevanz der von Freud entwickelten Differenz zwischen der narzisstischen und libidinösen Besetzung des Objekts. (shrink)

Drawing on previous empirical research, we provide an exemplary narrative to illustrate how patients have experienced hospital care organized according to evidence‐based fast‐track programmes. The aim of this paper was to analyse and discuss if and how it is possible to include patients’ individual perspectives in an evidence‐based practice as seen from the point of view of nursing theory. The paper highlights two conflicting courses of development. One is a course of standardization founded on evidence‐based recommendations, which specify a set (...) of rules that the patient must follow rigorously. The other is a course of democratization based on patients’ involvement in care. Referring to the analysis of the narrative, we argue that, in the current implementation of evidence‐based practice, the proposed involvement of patients resembles empty rhetoric. We argue that the principles and values from evidence‐based medicine are being lost in the transformation into the current evidence‐based hospital culture which potentially leads to a McDonaldization of nursing practice reflected as ‘one best way’. We argue for reviving ethics of care perspectives in today's evidence practice as the fundamental values of nursing may potentially bridge conflicts between evidence‐based practice and the ideals of patient participation thus preventing a practice of ‘McNursing’. (shrink)

Before the EU General Data Protection Regulation entered into force in May 2018, we witnessed an intense struggle of actors associated with data-dependent fields of science, in particular health-related academia and biobanks striving for legal derogations for data reuse in research. These actors engaged in a similar line of argument and formed issue alliances to pool their collective power. Using descriptive coding followed by an interpretive analysis, this article investigates the argumentative repertoire of these actors and embeds the analysis in (...) ethical debates on data sharing and biobank-related data governance. We observe efforts to perform a paradigmatic shift of the discourse around the General Data Protection Regulation-implementation away from ‘protecting data’ as key concern to ‘protecting health’ of individuals and societies at large. Instead of data protection, the key risks stressed by health researchers became potential obstacles to research. In line, exchange of information with data subjects is not a key concern in the arguments of biobank-related actors and it is assumed that patients want ‘their’ data to be used. We interpret these narratives as a ‘reaction’ to potential restrictions for data reuse and in line with a broader trend towards Big Data science, as the very idea of biobanking is conceptualized around long-term use of readily prepared data. We conclude that a sustainable implementation of biobanks needs not only to comply with the General Data Protection Regulation, but must proactively re-imagine its relation to citizens and data subjects in order to account for the various ways that science gets entangled with society. (shrink)

Bei Kant tauchen viele antike Autoren und Theorien auf. In dieser ersten Gesamtbearbeitung zum Thema wird gegen eine langjährige Forschungsmeinung gezeigt, dass nicht so sehr Platon und Aristoteles als vielmehr der hellenistischen Philosophie die entscheidende Rolle für sein Denken zukommt. Anhand der drei Kritiken werden Konstanzen und Umbrüche seines Antikeverständnisses herausgearbeitet und in ihren Konsequenzen für die Kantdeutung beleuchtet.

ZusammenfassungIm Mittelpunkt des Beitrags steht die Übertragung ausgewählter Kapitel aus den 1955 niedergelegten autobiographischen Erinnerungen des japanischen Bakteriologen Taichi Kitashima, in denen Kitashima stark persönlich gefärbt über seinen Aufenthalt in Marburg berichtet. Wie andere japanische Mediziner seiner Generation verbrachte Kitashima mehrere Jahre in Deutschland, um dort bei dem Serumforscher Emil von Behring zu arbeiten und sich weiterzubilden. Der Kontakt war über Kitashimas Lehrer Shibasaburô Kitasato zustande gekommen, mit dem Behring in Berlin über Fragen der Immunologie geforscht hatte. Im „Kommentar“ wird (...) diskutiert, inwieweit die von Kitashima in der zeitlichen Distanz von 50 Jahren getroffene Einschätzung des Deutschlandaufenthalts als „vergeudete Zeit“ als zutreffend anzusehen ist, welche Vorteile ihm aus den europäischen Kontakten, zu denen auch Begegnungen im Pariser Pasteur-Institut gehörten, erwuchsen und aus welchen Gründen sie im Nationalsozialismus wiederbelebt wurden. (shrink)

Emotive Interjections in British English: A corpus-based study on variation in acquisition, function and usage constitutes the first in-depth corpus-based study on the use of emotive interjections in Present Day British English. In a novel approach, it systematically distinguishes between child and adult speakers, providing new insights into how they use Ow!, Ouch!, Ugh!, Yuck!, Whoops!, Whoopsadaisy! and Wow! in everyday spoken language. It studies in detail their acquisition by children and pinpoints changes and developments in their use throughout early (...) childhood. The study highlights particularities displayed by child and adult speakers in general and identifies crucial differences regarding how adults use emotive interjections depending on whether they are interacting with children or other adults. This book thus offers an exhaustive overview on the functions of emotive interjections based on thorough empirical research and will appeal to linguists concerned with pragmatics, child language acquisition, the expression of emotion and interjections. (shrink)

This article discusses the effects of two trends in contemporary biomedicine that have so far been largely addressed separately: the steering of fields through programmatic “buzzwords” and the projectified nature of contemporary health research, care, and promotion. Drawing on a case study of an Austrian diversity-sensitive health promotion project related to obesity prevention, we show how the articulation of these trends—governance by buzzwords and projectification—often leads to not unproblematic and often paradoxical outcomes. Buzzwords such as “diversity” become especially important in (...) an innovation-driven environment encouraging a promissory rhetoric. At the same time, the project form shapes and restricts how buzzwords are articulated and translated into a specific project design. In our case study of an obesity prevention program, the need to translate diversity into a “doable” project encouraged the identification of seemingly clearly delineated target groups and thus promoted a rather narrow understanding of diversity, which stands in tension with much more fluid and context-sensitive ways of performing “diversity.” We show how actors grapple with these paradoxes. This restricts the full power a buzzword such as diversity could achieve in terms of social justice. (shrink)

Experimental research shows that human sentence processing uses information from different levels of linguistic analysis, for example, lexical and syntactic preferences as well as semantic plausibility. Existing computational models of human sentence processing, however, have focused primarily on lexico‐syntactic factors. Those models that do account for semantic plausibility effects lack a general model of human plausibility intuitions at the sentence level. Within a probabilistic framework, we propose a wide‐coverage model that both assigns thematic roles to verb–argument pairs and determines a (...) preferred interpretation by evaluating the plausibility of the resulting (verb, role, argument) triples. The model is trained on a corpus of role‐annotated language data. We also present a transparent integration of the semantic model with an incremental probabilistic parser. We demonstrate that both the semantic plausibility model and the combined syntax/semantics model predict judgment and reading time data from the experimental literature. (shrink)

Wang (_Philosophy & Technology_ 35, 2022) introduces a Foucauldian power account of algorithmic transparency. This short commentary explores when this power account is appropriate. It is first observed that the power account is a constructionist one, and that such accounts often come with both factual and evaluative claims. In an instance of Hume’s law, the evaluative claims do not follow from the factual claims, leaving open the question of how much constructionist commitment (Hacking, 1999) one should have. The concept of (...) acts in equilibrium (Nozick, 1981) is then used to explain how different individuals reading Wang can end up with different evaluative attitudes towards algorithmic transparency, despite factual agreement. The commentary concludes by situating constructionist commitment inside a larger question of how much to think of our actions, identifying conflicting arguments. (shrink)

Rooted in Assyriology with a strong interdisciplinary outlook, this book offers the first comprehensive study of ancient Mesopotamian notions of the human person, including semantic analyses of Akkadian terms for body parts and multiple ...

“To be the first one.” – On the first Nobel Prize in Physiology or Medicine awarded to Emil von Behring in 1901. The German immunologist Emil von Behring is the first Nobel Prize laureate in physiology or medicine. Behring received the award in 1901 “for his work on serum therapy, especially its application against diphtheria”. Behring's name was strongly connected with progress in the field of diphtheria research through various publications. This study contextualizes the awarding of Behring and shows that (...) not only significant scientific and practical results made him primus inter pares in the eyes of the Nobel committee, but also factors like Behring's representation in the daily press and the broad public interest in diphtheria research. After the beginning of the industrial serum production in 1894, Behring was not only a “visible scientist”, he was also portrayed as the “savior of the children” and so ranked among the “great men” of his era. The paper argues that his public visibility and the popularity of “Behring's Diphtherie-Heilmittel” became a strong argument in favor of Behring during the selection process of the first Nobel laureate. The first part of the paper discusses the Nobel Prize nomination procedure from the views of the scientific community. Drawing on personal papers of the extended Behring Archives, the second part focusses on Behring from a private perspective and sheds light on the meaning and importance of the award for Behring and his family. (shrink)

In this chapter, we outline the range of argument forms involving causation that can be found in everyday discourse. We also survey empirical work concerned with the generation and evaluation of such arguments. This survey makes clear that there is presently no unified body of research concerned with causal argument. We highlight the benefits of a unified treatment both for those interested in causal cognition and those interested in argumentation, and identify the key challenges that must be met for a (...) full understanding of causal argumentation. (shrink)

The growing field of evo-devo is increasingly demonstrating the complexity of steps involved in genetic, intracellular regulatory, and extracellular environmental control of the development of phenotypes. A key result of such work is an account for the remarkable plasticity of organismal form in many species based on relatively minor changes in regulation of highly conserved genes and genetic processes. Accounting for behavioral plasticity is of similar potential interest but has received far less attention. Of particular interest is plasticity in communication (...) systems, where human language represents an ultimate target for research. The present paper considers plasticity of language capabilities in a comparative framework, focusing attention on examples of a remarkable fact: Whereas there exist design features of mature human language that have never been observed to occur in non-humans in the wild, many of these features can be developed to notable extents when non-humans are enculturated through human training. These examples of enculturated developmental plasticity across extremely diverse taxa suggest, consistent with the evo-devo theme of highly conserved processes in evolution, that human language is founded in part on cognitive capabilities that are indeed ancient and that even modern humans show self-organized emergence of many language capabilities in the context of rich enculturation, built on the special social/ecological history of the hominin line. Human culture can thus be seen as a regulatory system encouraging language development in the context of a cognitive background with many highly conserved features. (shrink)

As more decisions are made by automated algorithmic systems, the transparency of these systems has come under scrutiny. While such transparency is typically seen as beneficial, there is a also a critical, Foucauldian account of it. From this perspective, worries have recently been articulated that algorithmic transparency can be used for manipulation, as part of a disciplinary power structure. Klenk (Philosophy & Technology 36, 79, 2023) recently argued that such manipulation should not be understood as exploitation of vulnerable victims, but (...) rather as indifference to whether the information provided enhances decision-making by revealing reasons. This short commentary on Klenk uses Berlin’s (1958) two concepts of liberty to further illuminate the concept of transparency as manipulation, finding alignment between positive liberty and the critical account. (shrink)

Recent advances in artificial intelligence offer many beneficial prospects. However, concerns have been raised about the opacity of decisions made by these systems, some of which have turned out to be biased in various ways. This article makes a contribution to a growing body of literature on how to make systems for automated decision-making more transparent, explainable, and fair by drawing attention to and further elaborating a distinction first made by Nozick between first-level bias in the application of standards and (...) second-level bias in the choice of standards, as well as a second distinction between discrimination and arbitrariness. Applying the typology developed, a number of illuminating observations are made. First, it is observed that some reported bias in automated decision-making is first-level arbitrariness, which can be alleviated by explainability techniques. However, such techniques have only a limited potential to alleviate first-level discrimination. Second, it is argued that second-level arbitrariness is probably quite common in automated decision-making. In contrast to first-level arbitrariness, however, second-level arbitrariness is not straightforward to detect automatically. Third, the prospects for alleviating arbitrariness are discussed. It is argued that detecting and alleviating second-level arbitrariness is a profound problem because there are many contrasting and sometimes conflicting standards from which to choose, and even when we make intentional efforts to choose standards for good reasons, some second-level arbitrariness remains. (shrink)